I thought the Response 2's to be one of Proac's triumphs to be honest, even at their inflated price when new.
In audiophool circles, Spendor are regarded as "Spendorszzzzzzzzz" as they don't have this artificial "speed" that is so well liked. The S8's sound magnifcently smooth, but involving and powerful. get them a few hands breadths from a back wall and nowhere near corners and perhaps consider cabling like the Chord Rumour that we mostly used with them. A clean, clear, slightly "assertive" sounding amp with a punchy but musical, bass performance would work best I feel.
The S8e's were a tad tauter low down and sounded a touch livelier as a result IIRC. A much underrated speaker I think.
Is your new room going to be able to take old S100/SP100's? These are too large for many of us, but the extra scale would be well worth while if you can get some space around them (stands aren't a problem if you know where to look).